MMP8
Functional Attributes in Pathways
-
Substrates : 128 entries in CutDB for M10.002
Ext
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Aggrecan 1 isoform 2 precursor
-
alpha 1 type I collagen preproprotein
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biglycan preproprotein
-
Brevican core protein precursor
-
chemokine (C-X-C motif) ligand 1
-
chemokine (C-X-C motif) ligand 5
-
chemokine (C-X-C motif) ligand 5 precursor
-
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
-
collagen type III alpha 1 preproprotein
-
collagen, type II, alpha 1 isoform 1 precursor
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collagen, type II, alpha 1 isoform 2 precursor
-
dentin sialophosphoprotein preproprotein
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fibrinogen, alpha chain isoform alpha preproprotein
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fibronectin 1 isoform 1 preproprotein
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fibronectin 1 isoform 2 preproprotein
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fibronectin 1 isoform 3 preproprotein
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fibronectin 1 isoform 4 preproprotein
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fibronectin 1 isoform 5 preproprotein
-
fibronectin 1 isoform 6 preproprotein
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fibronectin 1 isoform 7 preproprotein
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Golli-mbp isoform 1
-
Golli-mbp isoform 2
-
interleukin 8 precursor
-
laminin, gamma 2
-
matrix metalloproteinase-8
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myelin basic protein isoform 1
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myelin basic protein isoform 2
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myelin basic protein isoform 3
-
myelin basic protein isoform 4
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prolactin
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proline arginine-rich end leucine-rich repeat protein precursor
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serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
-
Small inducible cytokine a2 precursor
-
small inducible cytokine B10 precursor
-
Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) isoform a
-
Substrate Specificity -- Under development
-
Inhibitors -- Under development
-
Pathways -- Under development
Recent News and Literature
- Enhanced systemic matrix metalloproteinase...Ann Med. 2008 Oct 31:1-8.
- No Association of MMP-7,...Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2514-8.
- A trend of increase...J Periodontal Res. 2008 Dec;43(6):717-22. Epub 2008 Jul 3.
- Serum matrix metalloproteinase-8 is associated...Melanoma Res. 2008 Aug;18(4):268-73.
- Selective modulation of matrix...J Biol Chem. 2008 May 22;.
- Urinary matrix metalloproteinase -8, -9, -14 and their...Ann Med. 2008;40(4):312-20.
- Matrix metalloproteinase-8 functions as a metastasis...Cancer Res. 2008 Apr 15;68(8):2755-63.
- Collagenase-2 (matrix metalloproteinase-8) plays...Br J Cancer. 2008 Feb 5;.
- Matrix-metalloproteinase-14 deficiency in bone-marrow-derived...Circulation. 2008 Feb 19;117(7):931-9. Epub 2008 Feb 4.
- Matrix metalloproteinases-1 and -8 improve...Cancer Res. 2007 Nov 15;67(22):10664-8.
- Involvement of specific matrix...Mol Cancer Ther. 2007 Sep;6(9):2563-71.
- Triple-helical transition state analogues:...J Am Chem Soc. 2007 Aug 29;129(34):10408-17. Epub 2007 Aug 2.
- Human matrix metalloproteinase-8 gene...Mol Ther. 2007 Nov;15(11):1982-90. Epub 2007 Jul 24.
- The C-terminus of ephrin-B1...J Cell Sci. 2007 Jul 1;120(Pt 13):2179-89. Epub 2007 Jun 13.
- Increased inflammation delays wound...FASEB J. 2007 Mar 28;.
- MMPs, IL-1, and TNF are regulated...J Dent Res. 2007 Apr;86(4):347-51.
- Up-regulation of matrix metalloproteinase-8...Oral Oncol. 2007 Nov;43(10):1026-33. Epub 2007 Feb 15.
- Smoking modulates interleukin-6:interleukin-10 and RANKL:osteoprotegerin...J Periodontal Res. 2007 Apr;42(2):184-91.
- Matrix metalloproteinase polymorphisms and bladder...Cancer Res. 2006 Dec 15;66(24):11644-8.
- The matrix metalloproteinases (MMPS)...Front Biosci. 2007 Jan 1;12:649-59.
Structural Features
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNE
ETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINI
AFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISL
FWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDN
QRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Cross annotation in other databases
MMP8 in:
Gene Cards
- Diseases
- Expression
- SNP
- Drugs
Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS
Functional Attributes in Pathways
-
Substrates : 128 entries in CutDB for M10.002
Ext
- Aggrecan 1 isoform 2 precursor
- alpha 1 type I collagen preproprotein
- biglycan preproprotein
- Brevican core protein precursor
- chemokine (C-X-C motif) ligand 1
- chemokine (C-X-C motif) ligand 5
- chemokine (C-X-C motif) ligand 5 precursor
- chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
- collagen type III alpha 1 preproprotein
- collagen, type II, alpha 1 isoform 1 precursor
- collagen, type II, alpha 1 isoform 2 precursor
- dentin sialophosphoprotein preproprotein
- fibrinogen, alpha chain isoform alpha preproprotein
- fibronectin 1 isoform 1 preproprotein
- fibronectin 1 isoform 2 preproprotein
- fibronectin 1 isoform 3 preproprotein
- fibronectin 1 isoform 4 preproprotein
- fibronectin 1 isoform 5 preproprotein
- fibronectin 1 isoform 6 preproprotein
- fibronectin 1 isoform 7 preproprotein
- Golli-mbp isoform 1
- Golli-mbp isoform 2
- interleukin 8 precursor
- laminin, gamma 2
- matrix metalloproteinase-8
- myelin basic protein isoform 1
- myelin basic protein isoform 2
- myelin basic protein isoform 3
- myelin basic protein isoform 4
- prolactin
- proline arginine-rich end leucine-rich repeat protein precursor
- serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
- Small inducible cytokine a2 precursor
- small inducible cytokine B10 precursor
- Tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) isoform a
- Substrate Specificity -- Under development
- Inhibitors -- Under development
- Pathways -- Under development
Recent News and Literature
- Enhanced systemic matrix metalloproteinase...Ann Med. 2008 Oct 31:1-8.
- No Association of MMP-7,...Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2514-8.
- A trend of increase...J Periodontal Res. 2008 Dec;43(6):717-22. Epub 2008 Jul 3.
- Serum matrix metalloproteinase-8 is associated...Melanoma Res. 2008 Aug;18(4):268-73.
- Selective modulation of matrix...J Biol Chem. 2008 May 22;.
- Urinary matrix metalloproteinase -8, -9, -14 and their...Ann Med. 2008;40(4):312-20.
- Matrix metalloproteinase-8 functions as a metastasis...Cancer Res. 2008 Apr 15;68(8):2755-63.
- Collagenase-2 (matrix metalloproteinase-8) plays...Br J Cancer. 2008 Feb 5;.
- Matrix-metalloproteinase-14 deficiency in bone-marrow-derived...Circulation. 2008 Feb 19;117(7):931-9. Epub 2008 Feb 4.
- Matrix metalloproteinases-1 and -8 improve...Cancer Res. 2007 Nov 15;67(22):10664-8.
- Involvement of specific matrix...Mol Cancer Ther. 2007 Sep;6(9):2563-71.
- Triple-helical transition state analogues:...J Am Chem Soc. 2007 Aug 29;129(34):10408-17. Epub 2007 Aug 2.
- Human matrix metalloproteinase-8 gene...Mol Ther. 2007 Nov;15(11):1982-90. Epub 2007 Jul 24.
- The C-terminus of ephrin-B1...J Cell Sci. 2007 Jul 1;120(Pt 13):2179-89. Epub 2007 Jun 13.
- Increased inflammation delays wound...FASEB J. 2007 Mar 28;.
- MMPs, IL-1, and TNF are regulated...J Dent Res. 2007 Apr;86(4):347-51.
- Up-regulation of matrix metalloproteinase-8...Oral Oncol. 2007 Nov;43(10):1026-33. Epub 2007 Feb 15.
- Smoking modulates interleukin-6:interleukin-10 and RANKL:osteoprotegerin...J Periodontal Res. 2007 Apr;42(2):184-91.
- Matrix metalloproteinase polymorphisms and bladder...Cancer Res. 2006 Dec 15;66(24):11644-8.
- The matrix metalloproteinases (MMPS)...Front Biosci. 2007 Jan 1;12:649-59.
Structural Features
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNE
ETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINI
AFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYA
FRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISL
FWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDN
QRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
Cross annotation in other databases
MMP8 in:
- Gene Cards
- Diseases
- Expression
- SNP
- Drugs
- Other Links
- Human Protein Atlas
- iHOP
- GNF Sym Atlas
- NCBI Homologs
- OMIM
- MEROPS
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